Ten-year overall and progression-free survival were 83.9 ± 10.4% and 48.7 ± 14.2%, respectively. Five patients (23%) received radiation therapy and four (18%) systemic therapy. Of the 22 patients treated at SJCRH, 19 (86%) required cerebrospinal fluid diversion and seven (32%) underwent tumor-directed surgery. The most common presenting symptoms were related to increased intracranial pressure. Median age at diagnosis was 9.9 years (range, 0.01–20.5). Forty-five patients with TG were included. Longitudinal clinical data were summarized, imaging and pathology specimen centrally reviewed, and tumor material analyzed with targeted molecular testing and genome-wide DNA methylation profiling. Jude Children’s Research Hospital (SJCRH) between 19. We retrospectively studied TGs treated or referred for review at St. Risk factors associated with inferior outcome and long-term sequelae of TG have not been well-documented. There has been no detailed analysis of molecular alterations in TG. Tectal glioma (TG) is a rare low-grade tumor occurring predominantly in the pediatric population.
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